Abstract
The effects of 3 and 6 mgm./kgm. of aminophylline, and of 6 mgm./kgm. of aminophylline together with 150 mgm. of meperidine, upon the respiratory response to ascending concentrations of inspired and alveolar carbon dioxide were studied in normal subjects.
At an alveolar pCO2 of 46 mm. Hg, 3 and 6 mgm./kgm. of aminophylline increased respiratory minute volume 46 and 98 per cent, respectively; tidal volume was increased by both doses, respiratory rate only by the larger dose. The administration of aminophylline with meperidine counteracted most of the respiratory depressant effects of meperidine.
Footnotes
- Received April 7, 1955.
JPET articles become freely available 12 months after publication, and remain freely available for 5 years.Non-open access articles that fall outside this five year window are available only to institutional subscribers and current ASPET members, or through the article purchase feature at the bottom of the page.
|
Log in using your username and password
Purchase access
You may purchase access to this article. This will require you to create an account if you don't already have one.