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Journal of Pharmacology And Experimental Therapeutics Fast Forward
First published on April 27, 2006; DOI: 10.1124/jpet.106.103465

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Received for publication March 2, 2006.
Revised April 18, 2006.
Accepted for publication April 24, 2006.

Role of Matrix Metalloproteinases in Intestinal Inflammation

Carlos Medina 1 Marek Radomski 2*

1 University of Texas-Houston 2 Trinity College, Dublin

* Address correspondence to: E-mail: radomskm{at}tcd.ie

Abstract

Matrix Metalloproteinases (MMPs) and their endogenous inhibitors, TIMPs, are produced in the gastrointestinal tract by several structural cells. The balance between MMPs and TIMPs is essential for many physiological processes in the gut. However, imbalance between MMPs and TIMPs plays an important role in the pathophysiology of diverse intestinal inflammatory conditions. We review the role of the MMP/TIMP system the pathogenesis of intestinal inflammatory diseases and pharmacologic perspectives for the use of compounds that restore the MMP/TIMP balance.


Key words: Colitis, Crohn's disease, Inflammatory bowel disease, Matrix metalloproteinases, TIMP, Ulceraive Colitis


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[Abstract] [Full Text] [PDF]


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