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Journal of Pharmacology And Experimental Therapeutics Fast Forward
First published on November 30, 2004; DOI: 10.1124/jpet.104.076893

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Received for publication September 3, 2004.
Revised November 23, 2004.
Accepted for publication November 23, 2004.

Quantitative and fibre-selective evaluation of dose-dependent nerve blockade by intrathecal lidocaine in rats

Mayuko Oda 1*, Norihito Kitagawa 1, Bang-Xiang Yang 1, Tadahide Totoki 1, Masatoshi Morimoto 1

1 Saga Medical School

* Address correspondence to: E-mail: mayuko{at}mail.anes.saga-med.ac.jp

Abstract

We investigated whether cutaneous stimulus threshold (CST) as determined using a Neurometer could be utilized for quantitative and differential nerve evaluation of reversible and irreversible nerve block following intrathecal lidocaine administration in rats. Rats with intrathecal catheters were randomly assigned to one of 5 groups (saline, or 2%, 5%, 10%, or 20% lidocaine). Prior to and 4 days after drug administration, CST was determined at 5 Hz, 250 Hz and 2000 Hz. In the 2% lidocaine group, CST from end of lidocaine infusion to recovery from anesthesia was also monitored. Skin-clamp testing and gait observation were performed for comparison with CST findings. Behavioral examinations revealed persistent sensory or motor impairment lasting 4 days in groups receiving ≥5% lidocaine, but not in the saline and 2% lidocaine groups. With 2% lidocaine, return to baseline CSTs at 5 and 250 Hz was delayed compared to thresholds at 2000 Hz. Although CSTs in the 5% group at 5 and 250 Hz increased significantly, thresholds at 2000 Hz did not differ from those in rats administered saline. CSTs with ≥10% lidocaine displayed no differences between frequencies. At each frequency, CSTs for rats with ≥5% lidocaine increased in a clearly concentration-dependent manner. These results suggest that CST testing enables evaluation of the different nerve functions for A{beta}, A{delta}, and C fibers in rats for lidocaine concentrations ≤5%, and allows quantitative assessment of persistent neurological deficit induced by lidocaine in rats.


Key words: current stimulus threshold, different nerve assessment, lidocaine, neurometer, neurotoxicity, rat


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