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Received for publication February 18, 2004.
Revised April 12, 2004.
Accepted for publication April 13, 2004.
ABSTRACT Background: Smoking mentholated cigarettes has been suggested to convey a greater cancer risk compared to smoking nonmentholated cigarettes. Two of the possible mechanisms by which mentholated cigarette smoking could increase risk are by increasing systemic exposure to tobacco smoke toxins and by affecting the metabolism of nicotine or tobacco smoke carcinogens. Methods: To examine these possibilities, we performed a crossover study in 14 healthy smokers, half of whom were African-Americans and half whites. Subjects were randomly assigned to smoke mentholated or nonmentholated cigarettes for one week, then to cross over to the other type of cigarettes for another week. Subjects were confined to a Clinical Research Center for three days of each week, during which time blood levels of nicotine and carbon monoxide were measured throughout the day and an intravenous infusion of deuterium-labeled nicotine and cotinine was administered to determine the rate and pathways of nicotine metabolism. Results: The systemic intake of nicotine and carbon monoxide was, on average, not affected by mentholation of cigarettes. Mentholated cigarette smoking did significantly inhibit the metabolism of nicotine (clearance 1289 versus 1431 ml/min, two-sided, p = 0.02). Inhibition of nicotine metabolism occurred both by slower oxidative metabolism to cotinine and by slower glucuronide conjugation. Conclusions: Our data do not support the hypothesis that mentholated cigarette smoking results in a greater absorption of tobacco smoke toxins. Our finding of impaired metabolism of nicotine while mentholated cigarette smoking suggests that mentholated cigarette smoking enhances systemic nicotine exposure.
Key words:
Addiction, Dependence, Drug interactions, Drug metabolism, Nicotine, Pharmacokinetics
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