Identification and Characterization of Cholest-4-en-3-one, Oxime (TRO19622), a Novel Drug Candidate for Amyotrophic Lateral Sclerosis
J Pharmacol Exp Ther Bordet et al.
322: 709
Data Supplement
Files in this Data Supplement:
Data Supplement
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To allow us to perform medium-throughput screening on primary motor neurons, we
developed a new instrument...which allows rapid and fully automated
counting of single adherent cells (Supplemental Figure 1)...Interestingly, TRO19622 not only preserved motor
neuron cell bodies but also promoted neurite outgrowth as compared to DMSO-treated motor
neurons (Table 1 and Supplemental Figure 1).