Central Nervous System Drug Disposition: The Relationship between in Situ Brain Permeability and Brain Free Fraction
J Pharmacol Exp Ther Summerfield et al.
322: 205
Data Supplement
Files in this Data Supplement:
Data Supplement
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File 1.
Chemical structures for the 50 compound set.
Data Supplement
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File 2. This data file details the HPLC/MS/MS conditions used in the determination of permeability surface product (PS) following in situ brain rat brain perfusion and Papp following incubation in the MDR1-MDCKII cell system.
Data Supplement
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file 3. This data file details the HPLC/MS/MS conditions used in the determination of fu(brain) following equilibrium dialysis.