Data Supplement

Files in this Data Supplement:

• Data Supplement - This file contains:
  1. Structure vs. activity and toxicity of asterriquinone library;
  2. Structure vs. activity and toxicity of mono-indolyl-quinone library;
  3. The neural net dependency plots of TrkA activity. Panel A: by asterriquinone library. Panel B: by mono-indolyl-quinone library;
  4. Summary of linear regression models showing coefficient, partial F value, and t-probability for most important variables;
  5. Compound 5E5 has additive effects on TrkA activation of NGF and enhances NGF activation on ERK, while impairs NGF activation on Akt.