Characterization of the pH of Folate Receptor-Containing Endosomes and the Rate of Hydrolysis of Internalized Acid-Labile Folate-Drug Conjugates
J Pharmacol Exp Ther Yang et al.
321: 462
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Figure 1. To demonstrate the specificity and affinity of ALFR for the folate receptor, we examined the fluorescence intensity of KB cells treated with folate-rhodamine (25 nM; an established FR-specific ligand) in the presence of increasing concentrations of ALFR (0-200 nM). ..