(S)-1-((S)-2-{[1-(4-Amino-3-chloro-phenyl)-methanoyl]-amino}-3,3-dimethyl-butanoyl)-pyrrolidine-2-carboxylic acid ((2R,3S)-2-ethoxy-5-oxo-tetrahydro-furan-3-yl)-amide (VX-765), an Orally Available Selective Interleukin (IL)-Converting Enzyme/Caspase-1 Inhibitor, Exhibits Potent Anti-Inflammatory Activities by Inhibiting the Release of IL-1 and IL-18

Data Supplement

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• Data Supplement -

  Figure 1. Dose response curve for VRT-043198 (triangles) in hypoxia-induced apoptosis in NT2 cells. NT2 cells were incubated with 100% N2 at 37°C for 18 h in the presence or absence of compound…

  Figure 2. Dose response curve for VRT-043198 (triangles) and Vertex’s pancaspase inhibitor (circles) in anti-Fas antibody-induced apoptosis in Jurkat cells…