Efficacy of the MCHR1 Antagonist N-[3-(1-{[4-(3,4-Difluorophenoxy)phenyl]methyl}(4-piperidyl))-4-methylphenyl]-2-methylpropanamide (SNAP 94847) in Mouse Models of Anxiety and Depression following Acute and Chronic Administration Is Independent of Hippocampal Neurogenesis
J Pharmacol Exp Ther David et al.
321: 237
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Figure 1. Effects of acute, subchronic or chronic SNAP 94847 (20 mg/kg/day/day) treatment in the Mouse L/D Paradigm in Balb/cJ mice...
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Figure 2. Effects of chronic SNAP 94847 (20 mg/kg/day/day) treatment in the Mouse L/D Paradigm in Balb/cJ mice...
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Figure 3. Effect of an oral chronic treatment of either SNAP 94847 20 mg/kg/day in 129Sv strain, compared to imipramine 20 mg/kg/day or vehicle (¡) on the mouse body weight treated (n=15 animals) (fig 1A) or in Balb/cJ stain in comparison to escitalopram 5 mg/kg/day or vehicle on the mouse body weight treated (n=15 animals) (suppl. Fig 1B).
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Figure 4. Effects of chronic SNAP 94847 (20 mg/kg/day/day) treatment in the Mouse Forced Swim Test in Balb/cJ mice...