Data Supplement

Files in this Data Supplement:

• Data Supplement - This supplement contains:

  Supplementary Table 1a. Summary of crystallographic data and key interactions of R406 in Syk protein kinase domain (I358 – N635).

  Supplementary Table 1b. Non-bond interaction between R406 and SYK.

  Supplementary Figure 1. Pharmacological Parameters of R406 in Balb/c Mice

  Supplementary Table 2. R406 Effects on Bleeding Time in Mice.

  Supplementary Table 3. Inhibition of Platelet Aggregation in Blood from Human Volunteers treated with R406 (Phase I Clinical Study).

  SUPPLEMENTARY METHODS