Research ArticleCellular and Molecular
Claudin-5-Binders Enhance Permeation of Solutes across the Blood-Brain Barrier in a Mammalian Model
Yosuke Hashimoto, Keisuke Shirakura, Yoshiaki Okada, Hiroyuki Takeda, Kohki Endo, Maki Tamura, Akihiro Watari, Yoshifusa Sadamura, Tatsuya Sawasaki, Takefumi Doi, Kiyohito Yagi and Masuo Kondoh
Journal of Pharmacology and Experimental Therapeutics November 2017, 363 (2) 275-283; DOI: https://doi.org/10.1124/jpet.117.243014
Yosuke Hashimoto
Graduate School of Pharmaceutical Sciences, Osaka University, Osaka, Japan (Y.H., K.S., Y.O., A.W., T.D., K.Y., M.K.); Proteo-Science Center, Ehime University, Ehime, Japan (H.T., T.S.); and Life Science Research Laboratories, Wako Pure Chemical Industries, Ltd., Hyogo, Japan (K.E., M.T., Y.S.)
Keisuke Shirakura
Graduate School of Pharmaceutical Sciences, Osaka University, Osaka, Japan (Y.H., K.S., Y.O., A.W., T.D., K.Y., M.K.); Proteo-Science Center, Ehime University, Ehime, Japan (H.T., T.S.); and Life Science Research Laboratories, Wako Pure Chemical Industries, Ltd., Hyogo, Japan (K.E., M.T., Y.S.)
Yoshiaki Okada
Graduate School of Pharmaceutical Sciences, Osaka University, Osaka, Japan (Y.H., K.S., Y.O., A.W., T.D., K.Y., M.K.); Proteo-Science Center, Ehime University, Ehime, Japan (H.T., T.S.); and Life Science Research Laboratories, Wako Pure Chemical Industries, Ltd., Hyogo, Japan (K.E., M.T., Y.S.)
Hiroyuki Takeda
Graduate School of Pharmaceutical Sciences, Osaka University, Osaka, Japan (Y.H., K.S., Y.O., A.W., T.D., K.Y., M.K.); Proteo-Science Center, Ehime University, Ehime, Japan (H.T., T.S.); and Life Science Research Laboratories, Wako Pure Chemical Industries, Ltd., Hyogo, Japan (K.E., M.T., Y.S.)
Kohki Endo
Graduate School of Pharmaceutical Sciences, Osaka University, Osaka, Japan (Y.H., K.S., Y.O., A.W., T.D., K.Y., M.K.); Proteo-Science Center, Ehime University, Ehime, Japan (H.T., T.S.); and Life Science Research Laboratories, Wako Pure Chemical Industries, Ltd., Hyogo, Japan (K.E., M.T., Y.S.)
Maki Tamura
Graduate School of Pharmaceutical Sciences, Osaka University, Osaka, Japan (Y.H., K.S., Y.O., A.W., T.D., K.Y., M.K.); Proteo-Science Center, Ehime University, Ehime, Japan (H.T., T.S.); and Life Science Research Laboratories, Wako Pure Chemical Industries, Ltd., Hyogo, Japan (K.E., M.T., Y.S.)
Akihiro Watari
Graduate School of Pharmaceutical Sciences, Osaka University, Osaka, Japan (Y.H., K.S., Y.O., A.W., T.D., K.Y., M.K.); Proteo-Science Center, Ehime University, Ehime, Japan (H.T., T.S.); and Life Science Research Laboratories, Wako Pure Chemical Industries, Ltd., Hyogo, Japan (K.E., M.T., Y.S.)
Yoshifusa Sadamura
Graduate School of Pharmaceutical Sciences, Osaka University, Osaka, Japan (Y.H., K.S., Y.O., A.W., T.D., K.Y., M.K.); Proteo-Science Center, Ehime University, Ehime, Japan (H.T., T.S.); and Life Science Research Laboratories, Wako Pure Chemical Industries, Ltd., Hyogo, Japan (K.E., M.T., Y.S.)
Tatsuya Sawasaki
Graduate School of Pharmaceutical Sciences, Osaka University, Osaka, Japan (Y.H., K.S., Y.O., A.W., T.D., K.Y., M.K.); Proteo-Science Center, Ehime University, Ehime, Japan (H.T., T.S.); and Life Science Research Laboratories, Wako Pure Chemical Industries, Ltd., Hyogo, Japan (K.E., M.T., Y.S.)
Takefumi Doi
Graduate School of Pharmaceutical Sciences, Osaka University, Osaka, Japan (Y.H., K.S., Y.O., A.W., T.D., K.Y., M.K.); Proteo-Science Center, Ehime University, Ehime, Japan (H.T., T.S.); and Life Science Research Laboratories, Wako Pure Chemical Industries, Ltd., Hyogo, Japan (K.E., M.T., Y.S.)
Kiyohito Yagi
Graduate School of Pharmaceutical Sciences, Osaka University, Osaka, Japan (Y.H., K.S., Y.O., A.W., T.D., K.Y., M.K.); Proteo-Science Center, Ehime University, Ehime, Japan (H.T., T.S.); and Life Science Research Laboratories, Wako Pure Chemical Industries, Ltd., Hyogo, Japan (K.E., M.T., Y.S.)
Masuo Kondoh
Graduate School of Pharmaceutical Sciences, Osaka University, Osaka, Japan (Y.H., K.S., Y.O., A.W., T.D., K.Y., M.K.); Proteo-Science Center, Ehime University, Ehime, Japan (H.T., T.S.); and Life Science Research Laboratories, Wako Pure Chemical Industries, Ltd., Hyogo, Japan (K.E., M.T., Y.S.)
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In this issue
Research ArticleCellular and Molecular
Claudin-5 Binder Modulates Blood-Brain Barrier Permeability
Yosuke Hashimoto, Keisuke Shirakura, Yoshiaki Okada, Hiroyuki Takeda, Kohki Endo, Maki Tamura, Akihiro Watari, Yoshifusa Sadamura, Tatsuya Sawasaki, Takefumi Doi, Kiyohito Yagi and Masuo Kondoh
Journal of Pharmacology and Experimental Therapeutics November 1, 2017, 363 (2) 275-283; DOI: https://doi.org/10.1124/jpet.117.243014
Research ArticleCellular and Molecular
Claudin-5 Binder Modulates Blood-Brain Barrier Permeability
Yosuke Hashimoto, Keisuke Shirakura, Yoshiaki Okada, Hiroyuki Takeda, Kohki Endo, Maki Tamura, Akihiro Watari, Yoshifusa Sadamura, Tatsuya Sawasaki, Takefumi Doi, Kiyohito Yagi and Masuo Kondoh
Journal of Pharmacology and Experimental Therapeutics November 1, 2017, 363 (2) 275-283; DOI: https://doi.org/10.1124/jpet.117.243014
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