Research ArticleBehavioral Pharmacology
The Prodrug 4-Chlorokynurenine Causes Ketamine-Like Antidepressant Effects, but Not Side Effects, by NMDA/GlycineB-Site Inhibition
Panos Zanos, Sean C. Piantadosi, Hui-Qiu Wu, Heather J. Pribut, Matthew J. Dell, Adem Can, H. Ralph Snodgrass, Carlos A. Zarate Jr., Robert Schwarcz and Todd D. Gould
Journal of Pharmacology and Experimental Therapeutics October 2015, 355 (1) 76-85; DOI: https://doi.org/10.1124/jpet.115.225664
Panos Zanos
Department of Psychiatry (P.Z., S.C.P., H.-Q.W., H.J.P., M.J.D., A.C., R.S., T.D.G.), Maryland Psychiatric Research Center (H.-Q.W., R.S.), Department of Pharmacology (R.S., T.D.G.), Department of Anatomy and Neurobiology (T.D.G.), University of Maryland School of Medicine, Baltimore, Maryland; VistaGen Therapeutics, Inc., San Francisco, California (H.R.S.); Experimental Therapeutics and Pathophysiology Branch, Intramural Research Program, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland (C.A.Z.)
Sean C. Piantadosi
Department of Psychiatry (P.Z., S.C.P., H.-Q.W., H.J.P., M.J.D., A.C., R.S., T.D.G.), Maryland Psychiatric Research Center (H.-Q.W., R.S.), Department of Pharmacology (R.S., T.D.G.), Department of Anatomy and Neurobiology (T.D.G.), University of Maryland School of Medicine, Baltimore, Maryland; VistaGen Therapeutics, Inc., San Francisco, California (H.R.S.); Experimental Therapeutics and Pathophysiology Branch, Intramural Research Program, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland (C.A.Z.)
Hui-Qiu Wu
Department of Psychiatry (P.Z., S.C.P., H.-Q.W., H.J.P., M.J.D., A.C., R.S., T.D.G.), Maryland Psychiatric Research Center (H.-Q.W., R.S.), Department of Pharmacology (R.S., T.D.G.), Department of Anatomy and Neurobiology (T.D.G.), University of Maryland School of Medicine, Baltimore, Maryland; VistaGen Therapeutics, Inc., San Francisco, California (H.R.S.); Experimental Therapeutics and Pathophysiology Branch, Intramural Research Program, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland (C.A.Z.)
Heather J. Pribut
Department of Psychiatry (P.Z., S.C.P., H.-Q.W., H.J.P., M.J.D., A.C., R.S., T.D.G.), Maryland Psychiatric Research Center (H.-Q.W., R.S.), Department of Pharmacology (R.S., T.D.G.), Department of Anatomy and Neurobiology (T.D.G.), University of Maryland School of Medicine, Baltimore, Maryland; VistaGen Therapeutics, Inc., San Francisco, California (H.R.S.); Experimental Therapeutics and Pathophysiology Branch, Intramural Research Program, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland (C.A.Z.)
Matthew J. Dell
Department of Psychiatry (P.Z., S.C.P., H.-Q.W., H.J.P., M.J.D., A.C., R.S., T.D.G.), Maryland Psychiatric Research Center (H.-Q.W., R.S.), Department of Pharmacology (R.S., T.D.G.), Department of Anatomy and Neurobiology (T.D.G.), University of Maryland School of Medicine, Baltimore, Maryland; VistaGen Therapeutics, Inc., San Francisco, California (H.R.S.); Experimental Therapeutics and Pathophysiology Branch, Intramural Research Program, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland (C.A.Z.)
Adem Can
Department of Psychiatry (P.Z., S.C.P., H.-Q.W., H.J.P., M.J.D., A.C., R.S., T.D.G.), Maryland Psychiatric Research Center (H.-Q.W., R.S.), Department of Pharmacology (R.S., T.D.G.), Department of Anatomy and Neurobiology (T.D.G.), University of Maryland School of Medicine, Baltimore, Maryland; VistaGen Therapeutics, Inc., San Francisco, California (H.R.S.); Experimental Therapeutics and Pathophysiology Branch, Intramural Research Program, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland (C.A.Z.)
H. Ralph Snodgrass
Department of Psychiatry (P.Z., S.C.P., H.-Q.W., H.J.P., M.J.D., A.C., R.S., T.D.G.), Maryland Psychiatric Research Center (H.-Q.W., R.S.), Department of Pharmacology (R.S., T.D.G.), Department of Anatomy and Neurobiology (T.D.G.), University of Maryland School of Medicine, Baltimore, Maryland; VistaGen Therapeutics, Inc., San Francisco, California (H.R.S.); Experimental Therapeutics and Pathophysiology Branch, Intramural Research Program, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland (C.A.Z.)
Carlos A. Zarate Jr.
Department of Psychiatry (P.Z., S.C.P., H.-Q.W., H.J.P., M.J.D., A.C., R.S., T.D.G.), Maryland Psychiatric Research Center (H.-Q.W., R.S.), Department of Pharmacology (R.S., T.D.G.), Department of Anatomy and Neurobiology (T.D.G.), University of Maryland School of Medicine, Baltimore, Maryland; VistaGen Therapeutics, Inc., San Francisco, California (H.R.S.); Experimental Therapeutics and Pathophysiology Branch, Intramural Research Program, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland (C.A.Z.)
Robert Schwarcz
Department of Psychiatry (P.Z., S.C.P., H.-Q.W., H.J.P., M.J.D., A.C., R.S., T.D.G.), Maryland Psychiatric Research Center (H.-Q.W., R.S.), Department of Pharmacology (R.S., T.D.G.), Department of Anatomy and Neurobiology (T.D.G.), University of Maryland School of Medicine, Baltimore, Maryland; VistaGen Therapeutics, Inc., San Francisco, California (H.R.S.); Experimental Therapeutics and Pathophysiology Branch, Intramural Research Program, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland (C.A.Z.)
Todd D. Gould
Department of Psychiatry (P.Z., S.C.P., H.-Q.W., H.J.P., M.J.D., A.C., R.S., T.D.G.), Maryland Psychiatric Research Center (H.-Q.W., R.S.), Department of Pharmacology (R.S., T.D.G.), Department of Anatomy and Neurobiology (T.D.G.), University of Maryland School of Medicine, Baltimore, Maryland; VistaGen Therapeutics, Inc., San Francisco, California (H.R.S.); Experimental Therapeutics and Pathophysiology Branch, Intramural Research Program, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland (C.A.Z.)
JPET articles become freely available 12 months after publication, and remain freely available for 5 years.Non-open access articles that fall outside this five year window are available only to institutional subscribers and current ASPET members, or through the article purchase feature at the bottom of the page.
|
Log in using your username and password
Purchase access
You may purchase access to this article. This will require you to create an account if you don't already have one.
In this issue
Research ArticleBehavioral Pharmacology
Fast-Onset Antidepressant Effects of 4-Chlorokynurenine
Panos Zanos, Sean C. Piantadosi, Hui-Qiu Wu, Heather J. Pribut, Matthew J. Dell, Adem Can, H. Ralph Snodgrass, Carlos A. Zarate, Robert Schwarcz and Todd D. Gould
Journal of Pharmacology and Experimental Therapeutics October 1, 2015, 355 (1) 76-85; DOI: https://doi.org/10.1124/jpet.115.225664
Research ArticleBehavioral Pharmacology
Fast-Onset Antidepressant Effects of 4-Chlorokynurenine
Panos Zanos, Sean C. Piantadosi, Hui-Qiu Wu, Heather J. Pribut, Matthew J. Dell, Adem Can, H. Ralph Snodgrass, Carlos A. Zarate, Robert Schwarcz and Todd D. Gould
Journal of Pharmacology and Experimental Therapeutics October 1, 2015, 355 (1) 76-85; DOI: https://doi.org/10.1124/jpet.115.225664
Jump to section
Related Articles
Cited By...
More in this TOC Section
Similar Articles
Advertisement