Research ArticleChemotherapy, Antibiotics, and Gene Therapy
TD-19, an Erlotinib Derivative, Induces Epidermal Growth Factor Receptor Wild-Type Nonsmall-Cell Lung Cancer Apoptosis through CIP2A-Mediated Pathway
Ting-Ting Chao, Cheng-Yi Wang, Chih-Cheng Lai, Yen-Lin Chen, Yi-Ting Tsai, Pao-Tzu Chen, Hen-I Lin, Yuh-Chin T. Huang, Chung-Wai Shiau, Chong-Jen Yu and Kuen-Feng Chen
Journal of Pharmacology and Experimental Therapeutics November 2014, 351 (2) 352-358; DOI: https://doi.org/10.1124/jpet.114.215418
Ting-Ting Chao
Medical Research Center (T.-T.C., C.-Y.W., Y.-T.T., P.-T.C.), Department of Internal Medicine (C.-Y.W., H.-I.L.), and Department of Pathology (Y.-L.C.), Cardinal Tien Hospital, School of Medicine, Fu Jen Catholic University, New Taipei City, Taiwan; Graduate Institute of Clinical Medicine, College of Medicine, National Taiwan University, Taipei, Taiwan (C.-Y.W.); Department of Intensive Care Medicine, Chi Mei Medical Center, Liouying, Tainan, Taiwan (C.-C.L.); Department of Medicine, Duke University Medical Center, Durham, North Carolina (Y.-C.T.H.); Institute of Biopharmaceutical Sciences, National Yang-Ming University, Taipei, Taiwan (C.-W.S.); and Department of Internal Medicine (C.-J.Y.) and Department of Medical Research and National Center of Excellence for Clinical Trial and Research (K.-F.C.), National Taiwan University Hospital and National Taiwan University, Taipei, Taiwan
Cheng-Yi Wang
Medical Research Center (T.-T.C., C.-Y.W., Y.-T.T., P.-T.C.), Department of Internal Medicine (C.-Y.W., H.-I.L.), and Department of Pathology (Y.-L.C.), Cardinal Tien Hospital, School of Medicine, Fu Jen Catholic University, New Taipei City, Taiwan; Graduate Institute of Clinical Medicine, College of Medicine, National Taiwan University, Taipei, Taiwan (C.-Y.W.); Department of Intensive Care Medicine, Chi Mei Medical Center, Liouying, Tainan, Taiwan (C.-C.L.); Department of Medicine, Duke University Medical Center, Durham, North Carolina (Y.-C.T.H.); Institute of Biopharmaceutical Sciences, National Yang-Ming University, Taipei, Taiwan (C.-W.S.); and Department of Internal Medicine (C.-J.Y.) and Department of Medical Research and National Center of Excellence for Clinical Trial and Research (K.-F.C.), National Taiwan University Hospital and National Taiwan University, Taipei, Taiwan
Chih-Cheng Lai
Medical Research Center (T.-T.C., C.-Y.W., Y.-T.T., P.-T.C.), Department of Internal Medicine (C.-Y.W., H.-I.L.), and Department of Pathology (Y.-L.C.), Cardinal Tien Hospital, School of Medicine, Fu Jen Catholic University, New Taipei City, Taiwan; Graduate Institute of Clinical Medicine, College of Medicine, National Taiwan University, Taipei, Taiwan (C.-Y.W.); Department of Intensive Care Medicine, Chi Mei Medical Center, Liouying, Tainan, Taiwan (C.-C.L.); Department of Medicine, Duke University Medical Center, Durham, North Carolina (Y.-C.T.H.); Institute of Biopharmaceutical Sciences, National Yang-Ming University, Taipei, Taiwan (C.-W.S.); and Department of Internal Medicine (C.-J.Y.) and Department of Medical Research and National Center of Excellence for Clinical Trial and Research (K.-F.C.), National Taiwan University Hospital and National Taiwan University, Taipei, Taiwan
Yen-Lin Chen
Medical Research Center (T.-T.C., C.-Y.W., Y.-T.T., P.-T.C.), Department of Internal Medicine (C.-Y.W., H.-I.L.), and Department of Pathology (Y.-L.C.), Cardinal Tien Hospital, School of Medicine, Fu Jen Catholic University, New Taipei City, Taiwan; Graduate Institute of Clinical Medicine, College of Medicine, National Taiwan University, Taipei, Taiwan (C.-Y.W.); Department of Intensive Care Medicine, Chi Mei Medical Center, Liouying, Tainan, Taiwan (C.-C.L.); Department of Medicine, Duke University Medical Center, Durham, North Carolina (Y.-C.T.H.); Institute of Biopharmaceutical Sciences, National Yang-Ming University, Taipei, Taiwan (C.-W.S.); and Department of Internal Medicine (C.-J.Y.) and Department of Medical Research and National Center of Excellence for Clinical Trial and Research (K.-F.C.), National Taiwan University Hospital and National Taiwan University, Taipei, Taiwan
Yi-Ting Tsai
Medical Research Center (T.-T.C., C.-Y.W., Y.-T.T., P.-T.C.), Department of Internal Medicine (C.-Y.W., H.-I.L.), and Department of Pathology (Y.-L.C.), Cardinal Tien Hospital, School of Medicine, Fu Jen Catholic University, New Taipei City, Taiwan; Graduate Institute of Clinical Medicine, College of Medicine, National Taiwan University, Taipei, Taiwan (C.-Y.W.); Department of Intensive Care Medicine, Chi Mei Medical Center, Liouying, Tainan, Taiwan (C.-C.L.); Department of Medicine, Duke University Medical Center, Durham, North Carolina (Y.-C.T.H.); Institute of Biopharmaceutical Sciences, National Yang-Ming University, Taipei, Taiwan (C.-W.S.); and Department of Internal Medicine (C.-J.Y.) and Department of Medical Research and National Center of Excellence for Clinical Trial and Research (K.-F.C.), National Taiwan University Hospital and National Taiwan University, Taipei, Taiwan
Pao-Tzu Chen
Medical Research Center (T.-T.C., C.-Y.W., Y.-T.T., P.-T.C.), Department of Internal Medicine (C.-Y.W., H.-I.L.), and Department of Pathology (Y.-L.C.), Cardinal Tien Hospital, School of Medicine, Fu Jen Catholic University, New Taipei City, Taiwan; Graduate Institute of Clinical Medicine, College of Medicine, National Taiwan University, Taipei, Taiwan (C.-Y.W.); Department of Intensive Care Medicine, Chi Mei Medical Center, Liouying, Tainan, Taiwan (C.-C.L.); Department of Medicine, Duke University Medical Center, Durham, North Carolina (Y.-C.T.H.); Institute of Biopharmaceutical Sciences, National Yang-Ming University, Taipei, Taiwan (C.-W.S.); and Department of Internal Medicine (C.-J.Y.) and Department of Medical Research and National Center of Excellence for Clinical Trial and Research (K.-F.C.), National Taiwan University Hospital and National Taiwan University, Taipei, Taiwan
Hen-I Lin
Medical Research Center (T.-T.C., C.-Y.W., Y.-T.T., P.-T.C.), Department of Internal Medicine (C.-Y.W., H.-I.L.), and Department of Pathology (Y.-L.C.), Cardinal Tien Hospital, School of Medicine, Fu Jen Catholic University, New Taipei City, Taiwan; Graduate Institute of Clinical Medicine, College of Medicine, National Taiwan University, Taipei, Taiwan (C.-Y.W.); Department of Intensive Care Medicine, Chi Mei Medical Center, Liouying, Tainan, Taiwan (C.-C.L.); Department of Medicine, Duke University Medical Center, Durham, North Carolina (Y.-C.T.H.); Institute of Biopharmaceutical Sciences, National Yang-Ming University, Taipei, Taiwan (C.-W.S.); and Department of Internal Medicine (C.-J.Y.) and Department of Medical Research and National Center of Excellence for Clinical Trial and Research (K.-F.C.), National Taiwan University Hospital and National Taiwan University, Taipei, Taiwan
Yuh-Chin T. Huang
Medical Research Center (T.-T.C., C.-Y.W., Y.-T.T., P.-T.C.), Department of Internal Medicine (C.-Y.W., H.-I.L.), and Department of Pathology (Y.-L.C.), Cardinal Tien Hospital, School of Medicine, Fu Jen Catholic University, New Taipei City, Taiwan; Graduate Institute of Clinical Medicine, College of Medicine, National Taiwan University, Taipei, Taiwan (C.-Y.W.); Department of Intensive Care Medicine, Chi Mei Medical Center, Liouying, Tainan, Taiwan (C.-C.L.); Department of Medicine, Duke University Medical Center, Durham, North Carolina (Y.-C.T.H.); Institute of Biopharmaceutical Sciences, National Yang-Ming University, Taipei, Taiwan (C.-W.S.); and Department of Internal Medicine (C.-J.Y.) and Department of Medical Research and National Center of Excellence for Clinical Trial and Research (K.-F.C.), National Taiwan University Hospital and National Taiwan University, Taipei, Taiwan
Chung-Wai Shiau
Medical Research Center (T.-T.C., C.-Y.W., Y.-T.T., P.-T.C.), Department of Internal Medicine (C.-Y.W., H.-I.L.), and Department of Pathology (Y.-L.C.), Cardinal Tien Hospital, School of Medicine, Fu Jen Catholic University, New Taipei City, Taiwan; Graduate Institute of Clinical Medicine, College of Medicine, National Taiwan University, Taipei, Taiwan (C.-Y.W.); Department of Intensive Care Medicine, Chi Mei Medical Center, Liouying, Tainan, Taiwan (C.-C.L.); Department of Medicine, Duke University Medical Center, Durham, North Carolina (Y.-C.T.H.); Institute of Biopharmaceutical Sciences, National Yang-Ming University, Taipei, Taiwan (C.-W.S.); and Department of Internal Medicine (C.-J.Y.) and Department of Medical Research and National Center of Excellence for Clinical Trial and Research (K.-F.C.), National Taiwan University Hospital and National Taiwan University, Taipei, Taiwan
Chong-Jen Yu
Medical Research Center (T.-T.C., C.-Y.W., Y.-T.T., P.-T.C.), Department of Internal Medicine (C.-Y.W., H.-I.L.), and Department of Pathology (Y.-L.C.), Cardinal Tien Hospital, School of Medicine, Fu Jen Catholic University, New Taipei City, Taiwan; Graduate Institute of Clinical Medicine, College of Medicine, National Taiwan University, Taipei, Taiwan (C.-Y.W.); Department of Intensive Care Medicine, Chi Mei Medical Center, Liouying, Tainan, Taiwan (C.-C.L.); Department of Medicine, Duke University Medical Center, Durham, North Carolina (Y.-C.T.H.); Institute of Biopharmaceutical Sciences, National Yang-Ming University, Taipei, Taiwan (C.-W.S.); and Department of Internal Medicine (C.-J.Y.) and Department of Medical Research and National Center of Excellence for Clinical Trial and Research (K.-F.C.), National Taiwan University Hospital and National Taiwan University, Taipei, Taiwan
Kuen-Feng Chen
Medical Research Center (T.-T.C., C.-Y.W., Y.-T.T., P.-T.C.), Department of Internal Medicine (C.-Y.W., H.-I.L.), and Department of Pathology (Y.-L.C.), Cardinal Tien Hospital, School of Medicine, Fu Jen Catholic University, New Taipei City, Taiwan; Graduate Institute of Clinical Medicine, College of Medicine, National Taiwan University, Taipei, Taiwan (C.-Y.W.); Department of Intensive Care Medicine, Chi Mei Medical Center, Liouying, Tainan, Taiwan (C.-C.L.); Department of Medicine, Duke University Medical Center, Durham, North Carolina (Y.-C.T.H.); Institute of Biopharmaceutical Sciences, National Yang-Ming University, Taipei, Taiwan (C.-W.S.); and Department of Internal Medicine (C.-J.Y.) and Department of Medical Research and National Center of Excellence for Clinical Trial and Research (K.-F.C.), National Taiwan University Hospital and National Taiwan University, Taipei, Taiwan
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In this issue
Research ArticleChemotherapy, Antibiotics, and Gene Therapy
TD-19 Induces EGFR Wild-Type NSCLC Apoptosis
Ting-Ting Chao, Cheng-Yi Wang, Chih-Cheng Lai, Yen-Lin Chen, Yi-Ting Tsai, Pao-Tzu Chen, Hen-I Lin, Yuh-Chin T. Huang, Chung-Wai Shiau, Chong-Jen Yu and Kuen-Feng Chen
Journal of Pharmacology and Experimental Therapeutics November 1, 2014, 351 (2) 352-358; DOI: https://doi.org/10.1124/jpet.114.215418
Research ArticleChemotherapy, Antibiotics, and Gene Therapy
TD-19 Induces EGFR Wild-Type NSCLC Apoptosis
Ting-Ting Chao, Cheng-Yi Wang, Chih-Cheng Lai, Yen-Lin Chen, Yi-Ting Tsai, Pao-Tzu Chen, Hen-I Lin, Yuh-Chin T. Huang, Chung-Wai Shiau, Chong-Jen Yu and Kuen-Feng Chen
Journal of Pharmacology and Experimental Therapeutics November 1, 2014, 351 (2) 352-358; DOI: https://doi.org/10.1124/jpet.114.215418
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