Research ArticleCellular and Molecular
Distinct Properties of Telmisartan on Agonistic Activities for Peroxisome Proliferator-Activated Receptor γ among Clinically Used Angiotensin II Receptor Blockers: Drug-Target Interaction Analyses
Hirotoshi Kakuta, Eiji Kurosaki, Tatsuya Niimi, Katsuhiko Gato, Yuko Kawasaki, Akira Suwa, Kazuya Honbou, Tomohiko Yamaguchi, Hiroyuki Okumura, Masanao Sanagi, Yuichi Tomura, Masaya Orita, Takako Yonemoto and Hiroaki Masuzaki
Journal of Pharmacology and Experimental Therapeutics April 2014, 349 (1) 10-20; DOI: https://doi.org/10.1124/jpet.113.211722
Hirotoshi Kakuta
Drug Discovery Research, Astellas Pharma, Inc., Ibaraki, Japan (H.K., E.K., T.N., K.G., Y.K., A.S., K.H., T.Y., M.S., Y.T., M.O.);Medical Affairs, Astellas Pharma, Inc., Tokyo, Japan (H.O.); Shizuoka Prefectural General Hospital, Shizuoka, Japan (T.Y.); and Division of Endocrinology, Diabetes and Metabolism, Hematology, Rheumatology (Second Department of Internal Medicine), Graduate School of Medicine, University of the Ryukyus, Okinawa, Japan (H.M.)
Eiji Kurosaki
Drug Discovery Research, Astellas Pharma, Inc., Ibaraki, Japan (H.K., E.K., T.N., K.G., Y.K., A.S., K.H., T.Y., M.S., Y.T., M.O.);Medical Affairs, Astellas Pharma, Inc., Tokyo, Japan (H.O.); Shizuoka Prefectural General Hospital, Shizuoka, Japan (T.Y.); and Division of Endocrinology, Diabetes and Metabolism, Hematology, Rheumatology (Second Department of Internal Medicine), Graduate School of Medicine, University of the Ryukyus, Okinawa, Japan (H.M.)
Tatsuya Niimi
Drug Discovery Research, Astellas Pharma, Inc., Ibaraki, Japan (H.K., E.K., T.N., K.G., Y.K., A.S., K.H., T.Y., M.S., Y.T., M.O.);Medical Affairs, Astellas Pharma, Inc., Tokyo, Japan (H.O.); Shizuoka Prefectural General Hospital, Shizuoka, Japan (T.Y.); and Division of Endocrinology, Diabetes and Metabolism, Hematology, Rheumatology (Second Department of Internal Medicine), Graduate School of Medicine, University of the Ryukyus, Okinawa, Japan (H.M.)
Katsuhiko Gato
Drug Discovery Research, Astellas Pharma, Inc., Ibaraki, Japan (H.K., E.K., T.N., K.G., Y.K., A.S., K.H., T.Y., M.S., Y.T., M.O.);Medical Affairs, Astellas Pharma, Inc., Tokyo, Japan (H.O.); Shizuoka Prefectural General Hospital, Shizuoka, Japan (T.Y.); and Division of Endocrinology, Diabetes and Metabolism, Hematology, Rheumatology (Second Department of Internal Medicine), Graduate School of Medicine, University of the Ryukyus, Okinawa, Japan (H.M.)
Yuko Kawasaki
Drug Discovery Research, Astellas Pharma, Inc., Ibaraki, Japan (H.K., E.K., T.N., K.G., Y.K., A.S., K.H., T.Y., M.S., Y.T., M.O.);Medical Affairs, Astellas Pharma, Inc., Tokyo, Japan (H.O.); Shizuoka Prefectural General Hospital, Shizuoka, Japan (T.Y.); and Division of Endocrinology, Diabetes and Metabolism, Hematology, Rheumatology (Second Department of Internal Medicine), Graduate School of Medicine, University of the Ryukyus, Okinawa, Japan (H.M.)
Akira Suwa
Drug Discovery Research, Astellas Pharma, Inc., Ibaraki, Japan (H.K., E.K., T.N., K.G., Y.K., A.S., K.H., T.Y., M.S., Y.T., M.O.);Medical Affairs, Astellas Pharma, Inc., Tokyo, Japan (H.O.); Shizuoka Prefectural General Hospital, Shizuoka, Japan (T.Y.); and Division of Endocrinology, Diabetes and Metabolism, Hematology, Rheumatology (Second Department of Internal Medicine), Graduate School of Medicine, University of the Ryukyus, Okinawa, Japan (H.M.)
Kazuya Honbou
Drug Discovery Research, Astellas Pharma, Inc., Ibaraki, Japan (H.K., E.K., T.N., K.G., Y.K., A.S., K.H., T.Y., M.S., Y.T., M.O.);Medical Affairs, Astellas Pharma, Inc., Tokyo, Japan (H.O.); Shizuoka Prefectural General Hospital, Shizuoka, Japan (T.Y.); and Division of Endocrinology, Diabetes and Metabolism, Hematology, Rheumatology (Second Department of Internal Medicine), Graduate School of Medicine, University of the Ryukyus, Okinawa, Japan (H.M.)
Tomohiko Yamaguchi
Drug Discovery Research, Astellas Pharma, Inc., Ibaraki, Japan (H.K., E.K., T.N., K.G., Y.K., A.S., K.H., T.Y., M.S., Y.T., M.O.);Medical Affairs, Astellas Pharma, Inc., Tokyo, Japan (H.O.); Shizuoka Prefectural General Hospital, Shizuoka, Japan (T.Y.); and Division of Endocrinology, Diabetes and Metabolism, Hematology, Rheumatology (Second Department of Internal Medicine), Graduate School of Medicine, University of the Ryukyus, Okinawa, Japan (H.M.)
Hiroyuki Okumura
Drug Discovery Research, Astellas Pharma, Inc., Ibaraki, Japan (H.K., E.K., T.N., K.G., Y.K., A.S., K.H., T.Y., M.S., Y.T., M.O.);Medical Affairs, Astellas Pharma, Inc., Tokyo, Japan (H.O.); Shizuoka Prefectural General Hospital, Shizuoka, Japan (T.Y.); and Division of Endocrinology, Diabetes and Metabolism, Hematology, Rheumatology (Second Department of Internal Medicine), Graduate School of Medicine, University of the Ryukyus, Okinawa, Japan (H.M.)
Masanao Sanagi
Drug Discovery Research, Astellas Pharma, Inc., Ibaraki, Japan (H.K., E.K., T.N., K.G., Y.K., A.S., K.H., T.Y., M.S., Y.T., M.O.);Medical Affairs, Astellas Pharma, Inc., Tokyo, Japan (H.O.); Shizuoka Prefectural General Hospital, Shizuoka, Japan (T.Y.); and Division of Endocrinology, Diabetes and Metabolism, Hematology, Rheumatology (Second Department of Internal Medicine), Graduate School of Medicine, University of the Ryukyus, Okinawa, Japan (H.M.)
Yuichi Tomura
Drug Discovery Research, Astellas Pharma, Inc., Ibaraki, Japan (H.K., E.K., T.N., K.G., Y.K., A.S., K.H., T.Y., M.S., Y.T., M.O.);Medical Affairs, Astellas Pharma, Inc., Tokyo, Japan (H.O.); Shizuoka Prefectural General Hospital, Shizuoka, Japan (T.Y.); and Division of Endocrinology, Diabetes and Metabolism, Hematology, Rheumatology (Second Department of Internal Medicine), Graduate School of Medicine, University of the Ryukyus, Okinawa, Japan (H.M.)
Masaya Orita
Drug Discovery Research, Astellas Pharma, Inc., Ibaraki, Japan (H.K., E.K., T.N., K.G., Y.K., A.S., K.H., T.Y., M.S., Y.T., M.O.);Medical Affairs, Astellas Pharma, Inc., Tokyo, Japan (H.O.); Shizuoka Prefectural General Hospital, Shizuoka, Japan (T.Y.); and Division of Endocrinology, Diabetes and Metabolism, Hematology, Rheumatology (Second Department of Internal Medicine), Graduate School of Medicine, University of the Ryukyus, Okinawa, Japan (H.M.)
Takako Yonemoto
Drug Discovery Research, Astellas Pharma, Inc., Ibaraki, Japan (H.K., E.K., T.N., K.G., Y.K., A.S., K.H., T.Y., M.S., Y.T., M.O.);Medical Affairs, Astellas Pharma, Inc., Tokyo, Japan (H.O.); Shizuoka Prefectural General Hospital, Shizuoka, Japan (T.Y.); and Division of Endocrinology, Diabetes and Metabolism, Hematology, Rheumatology (Second Department of Internal Medicine), Graduate School of Medicine, University of the Ryukyus, Okinawa, Japan (H.M.)
Hiroaki Masuzaki
Drug Discovery Research, Astellas Pharma, Inc., Ibaraki, Japan (H.K., E.K., T.N., K.G., Y.K., A.S., K.H., T.Y., M.S., Y.T., M.O.);Medical Affairs, Astellas Pharma, Inc., Tokyo, Japan (H.O.); Shizuoka Prefectural General Hospital, Shizuoka, Japan (T.Y.); and Division of Endocrinology, Diabetes and Metabolism, Hematology, Rheumatology (Second Department of Internal Medicine), Graduate School of Medicine, University of the Ryukyus, Okinawa, Japan (H.M.)
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In this issue
Research ArticleCellular and Molecular
Distinct Interaction of Telmisartan-PPARγ
Hirotoshi Kakuta, Eiji Kurosaki, Tatsuya Niimi, Katsuhiko Gato, Yuko Kawasaki, Akira Suwa, Kazuya Honbou, Tomohiko Yamaguchi, Hiroyuki Okumura, Masanao Sanagi, Yuichi Tomura, Masaya Orita, Takako Yonemoto and Hiroaki Masuzaki
Journal of Pharmacology and Experimental Therapeutics April 1, 2014, 349 (1) 10-20; DOI: https://doi.org/10.1124/jpet.113.211722
Research ArticleCellular and Molecular
Distinct Interaction of Telmisartan-PPARγ
Hirotoshi Kakuta, Eiji Kurosaki, Tatsuya Niimi, Katsuhiko Gato, Yuko Kawasaki, Akira Suwa, Kazuya Honbou, Tomohiko Yamaguchi, Hiroyuki Okumura, Masanao Sanagi, Yuichi Tomura, Masaya Orita, Takako Yonemoto and Hiroaki Masuzaki
Journal of Pharmacology and Experimental Therapeutics April 1, 2014, 349 (1) 10-20; DOI: https://doi.org/10.1124/jpet.113.211722
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