Research ArticleCardiovascular
Catharanthine Dilates Small Mesenteric Arteries and Decreases Heart Rate and Cardiac Contractility by Inhibition of Voltage-Operated Calcium Channels on Vascular Smooth Muscle Cells and Cardiomyocytes
Ashok Jadhav, Wenbin Liang, Peter C. Papageorgiou, Ahmed Shoker, Selliah C. Kanthan, John Balsevich, Andrew S. Levy, Scott Heximer, Peter H. Backx and Venkat Gopalakrishnan
Journal of Pharmacology and Experimental Therapeutics June 2013, 345 (3) 383-392; DOI: https://doi.org/10.1124/jpet.112.199661
Ashok Jadhav
Departments of Pharmacology (A.J., V.G.), Medicine (A.S.), and Surgery (S.C.K.), College of Medicine, University of Saskatchewan, Saskatoon, Saskatchewan, Canada; Departments of Physiology and Medicine, Heart & Stroke/Richard Lewar Centre of Excellence, University of Toronto, Toronto, Ontario, Canada (W.L., P.C.P., A.S.L., S.H., P.H.B.); Department of Medicine, Division of Cardiology, University Health Network and Mount Sinai Hospital, University of Toronto, Toronto, Ontario, Canada (P.C.P., P.H.B.); and Plant Biotechnology Institute, National Research Council of Canada, Saskatoon, Saskatchewan, Canada (J.B.)
Wenbin Liang
Departments of Pharmacology (A.J., V.G.), Medicine (A.S.), and Surgery (S.C.K.), College of Medicine, University of Saskatchewan, Saskatoon, Saskatchewan, Canada; Departments of Physiology and Medicine, Heart & Stroke/Richard Lewar Centre of Excellence, University of Toronto, Toronto, Ontario, Canada (W.L., P.C.P., A.S.L., S.H., P.H.B.); Department of Medicine, Division of Cardiology, University Health Network and Mount Sinai Hospital, University of Toronto, Toronto, Ontario, Canada (P.C.P., P.H.B.); and Plant Biotechnology Institute, National Research Council of Canada, Saskatoon, Saskatchewan, Canada (J.B.)
Peter C. Papageorgiou
Departments of Pharmacology (A.J., V.G.), Medicine (A.S.), and Surgery (S.C.K.), College of Medicine, University of Saskatchewan, Saskatoon, Saskatchewan, Canada; Departments of Physiology and Medicine, Heart & Stroke/Richard Lewar Centre of Excellence, University of Toronto, Toronto, Ontario, Canada (W.L., P.C.P., A.S.L., S.H., P.H.B.); Department of Medicine, Division of Cardiology, University Health Network and Mount Sinai Hospital, University of Toronto, Toronto, Ontario, Canada (P.C.P., P.H.B.); and Plant Biotechnology Institute, National Research Council of Canada, Saskatoon, Saskatchewan, Canada (J.B.)
Ahmed Shoker
Departments of Pharmacology (A.J., V.G.), Medicine (A.S.), and Surgery (S.C.K.), College of Medicine, University of Saskatchewan, Saskatoon, Saskatchewan, Canada; Departments of Physiology and Medicine, Heart & Stroke/Richard Lewar Centre of Excellence, University of Toronto, Toronto, Ontario, Canada (W.L., P.C.P., A.S.L., S.H., P.H.B.); Department of Medicine, Division of Cardiology, University Health Network and Mount Sinai Hospital, University of Toronto, Toronto, Ontario, Canada (P.C.P., P.H.B.); and Plant Biotechnology Institute, National Research Council of Canada, Saskatoon, Saskatchewan, Canada (J.B.)
Selliah C. Kanthan
Departments of Pharmacology (A.J., V.G.), Medicine (A.S.), and Surgery (S.C.K.), College of Medicine, University of Saskatchewan, Saskatoon, Saskatchewan, Canada; Departments of Physiology and Medicine, Heart & Stroke/Richard Lewar Centre of Excellence, University of Toronto, Toronto, Ontario, Canada (W.L., P.C.P., A.S.L., S.H., P.H.B.); Department of Medicine, Division of Cardiology, University Health Network and Mount Sinai Hospital, University of Toronto, Toronto, Ontario, Canada (P.C.P., P.H.B.); and Plant Biotechnology Institute, National Research Council of Canada, Saskatoon, Saskatchewan, Canada (J.B.)
John Balsevich
Departments of Pharmacology (A.J., V.G.), Medicine (A.S.), and Surgery (S.C.K.), College of Medicine, University of Saskatchewan, Saskatoon, Saskatchewan, Canada; Departments of Physiology and Medicine, Heart & Stroke/Richard Lewar Centre of Excellence, University of Toronto, Toronto, Ontario, Canada (W.L., P.C.P., A.S.L., S.H., P.H.B.); Department of Medicine, Division of Cardiology, University Health Network and Mount Sinai Hospital, University of Toronto, Toronto, Ontario, Canada (P.C.P., P.H.B.); and Plant Biotechnology Institute, National Research Council of Canada, Saskatoon, Saskatchewan, Canada (J.B.)
Andrew S. Levy
Departments of Pharmacology (A.J., V.G.), Medicine (A.S.), and Surgery (S.C.K.), College of Medicine, University of Saskatchewan, Saskatoon, Saskatchewan, Canada; Departments of Physiology and Medicine, Heart & Stroke/Richard Lewar Centre of Excellence, University of Toronto, Toronto, Ontario, Canada (W.L., P.C.P., A.S.L., S.H., P.H.B.); Department of Medicine, Division of Cardiology, University Health Network and Mount Sinai Hospital, University of Toronto, Toronto, Ontario, Canada (P.C.P., P.H.B.); and Plant Biotechnology Institute, National Research Council of Canada, Saskatoon, Saskatchewan, Canada (J.B.)
Scott Heximer
Departments of Pharmacology (A.J., V.G.), Medicine (A.S.), and Surgery (S.C.K.), College of Medicine, University of Saskatchewan, Saskatoon, Saskatchewan, Canada; Departments of Physiology and Medicine, Heart & Stroke/Richard Lewar Centre of Excellence, University of Toronto, Toronto, Ontario, Canada (W.L., P.C.P., A.S.L., S.H., P.H.B.); Department of Medicine, Division of Cardiology, University Health Network and Mount Sinai Hospital, University of Toronto, Toronto, Ontario, Canada (P.C.P., P.H.B.); and Plant Biotechnology Institute, National Research Council of Canada, Saskatoon, Saskatchewan, Canada (J.B.)
Peter H. Backx
Departments of Pharmacology (A.J., V.G.), Medicine (A.S.), and Surgery (S.C.K.), College of Medicine, University of Saskatchewan, Saskatoon, Saskatchewan, Canada; Departments of Physiology and Medicine, Heart & Stroke/Richard Lewar Centre of Excellence, University of Toronto, Toronto, Ontario, Canada (W.L., P.C.P., A.S.L., S.H., P.H.B.); Department of Medicine, Division of Cardiology, University Health Network and Mount Sinai Hospital, University of Toronto, Toronto, Ontario, Canada (P.C.P., P.H.B.); and Plant Biotechnology Institute, National Research Council of Canada, Saskatoon, Saskatchewan, Canada (J.B.)
Venkat Gopalakrishnan
Departments of Pharmacology (A.J., V.G.), Medicine (A.S.), and Surgery (S.C.K.), College of Medicine, University of Saskatchewan, Saskatoon, Saskatchewan, Canada; Departments of Physiology and Medicine, Heart & Stroke/Richard Lewar Centre of Excellence, University of Toronto, Toronto, Ontario, Canada (W.L., P.C.P., A.S.L., S.H., P.H.B.); Department of Medicine, Division of Cardiology, University Health Network and Mount Sinai Hospital, University of Toronto, Toronto, Ontario, Canada (P.C.P., P.H.B.); and Plant Biotechnology Institute, National Research Council of Canada, Saskatoon, Saskatchewan, Canada (J.B.)
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In this issue
Research ArticleCardiovascular
Catharanthine Blocks Voltage-Operated Ca2+ Channels
Ashok Jadhav, Wenbin Liang, Peter C. Papageorgiou, Ahmed Shoker, Selliah C. Kanthan, John Balsevich, Andrew S. Levy, Scott Heximer, Peter H. Backx and Venkat Gopalakrishnan
Journal of Pharmacology and Experimental Therapeutics June 1, 2013, 345 (3) 383-392; DOI: https://doi.org/10.1124/jpet.112.199661
Research ArticleCardiovascular
Catharanthine Blocks Voltage-Operated Ca2+ Channels
Ashok Jadhav, Wenbin Liang, Peter C. Papageorgiou, Ahmed Shoker, Selliah C. Kanthan, John Balsevich, Andrew S. Levy, Scott Heximer, Peter H. Backx and Venkat Gopalakrishnan
Journal of Pharmacology and Experimental Therapeutics June 1, 2013, 345 (3) 383-392; DOI: https://doi.org/10.1124/jpet.112.199661
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