Fig. 2.   Dose-response effect of fluoxetine on the oxytocin response to 8-OH-DPAT (50 µg/kg s.c.). A, experiment 1 using fluoxetine doses of 0.3, 1, 3, and 10 mg/kg/day; B, experiment 2 with fluoxetine doses of 5, 7.5, and 10 mg/kg/day. The data represent the mean ± S.E.M. of 8 to 12 rats per group. A, the two-way ANOVA indicated the following: main effect of fluoxetine dose F(4,60) = 4.75, p < 0.01; main effect of 8-OH-DPAT F(1,60) = 48.60, p < 0.01; fluoxetine dose × 8-OH-DPAT, F(4,60) = 4.86, p < 0.01. B, the two-way ANOVA indicated the following: main effect of fluoxetine dose F(3,66) = 16.36, p < 0.01; main effect of 8-OH-DPAT F(1,66) = 86.30, p < 0.01; fluoxetine dose × 8-OH-DPAT, F(3,66) = 17.44, p < 0.01. The posthoc Newman-Keuls' tests indicated the following: *significant difference from the rats challenged with saline (0 dose of 8-OH-DPAT), p < 0.01; #significant difference from the vehicle rats (0 dose of fluoxetine) challenged with 8-OH-DPAT, p < 0.01.

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