Fig. 2.   Recordings of I_Kr, I_to (A and B) and I_K1 (C) in the same cell before and after 5-min superfusion with 10 µmol/l tamoxifen. A, I_Kr and I_to currents recorded before and after superfusion with tamoxifen. Tamoxifen abolished the I_Kr tail current and also reduced the time-dependent I_Kr current, without affecting the transient outward current (I_to). B, Tamoxifen-sensitive currents obtained by digital subtraction of currents before and after tamoxifen superfusion. Note the inward rectification of the time-dependent I_Kr currents at very positive potentials compared with the tail currents and their similarity to the E-4031 sensitive currents. C, I_K1 current recorded before and after superfusion with tamoxifen. Tamoxifen showed no block of I_K1 inward current. The outward holding currents that represent the amplitude of I_K1 at 40 mV are superimposed.

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