PHARMACOLOGY OF N-(2-FURFURYL)-N-(2-PYRIDYL)-N' ,N'-,DIMETHYLETHYLENEDIAMINE FUMARATE (METHAFURYLENEFUMARATE). II. TOXICOLOGICAL STUDIES

¹ Division of Pharmacology, Eaton Laboratories, Inc., Norwich, New York

The peroral LD₅₀ of F-151 in white mice was in the neighborhood of 350 mgm./kgm., varying somewhat with sex and with strain. The mean intraperitoneal LD₅₀ of F-151 in mongrel female white mice was 136 mgm./kgm. These figures are approximately twice the respective LD₅₀'s of tripelennamine hydrochloride observed in the same strains of mice.

Available data indicate that the lethal dose of F-151 in guinea pigs, rats, or cats is of the same order of magnitude as that in mice.

Aside from a thick, mucoid sialogogic effect in cats and dogs, all toxic symptoms were attributable to stimulation of the central nervous system. All of the fatalities observed following administration of single doses occurred during convulsions.

Rats fed 1.8, 10, or 59 mgm./kgm./day for one year, and dogs fed 10 mgm./kgm./day for six months, showed no significant toxic effects as measured by behavior, growth, nutrition, serial hematological examination, and gross and microscopic examination of the tissues.

Dogs fed 32 or 60 mgm./kgm./day for six months frequently experienced convulsive seizures and other central nervous symptoms, of short duration, following administration of an individual daily dose. There were no other abnormalities in these animals.