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Journal of Pharmacology And Experimental Therapeutics, Vol. 99, Issue 4, 458-464, 1950
Copyright © 1950 by American Society for Pharmacology and Experimental Therapeutics

THE NEUROMUSCULAR BLOCKING ACTION OF SUCCINYLCHOLINE (DIACETYLCHOLINE)

JULIO C. CASTILLO 1 and EDWIN J. de BEER 1

1 The Wellcome Research Laboratories, Tuckahoe, New York

Succinyicholine (diacetyicholine) has been found to exhibit strong neuromuscular blocking action in the cat, rabbit and mouse but the paralysis is of relatively short duration. This action can be greatly prolonged by eserine and evidence is presented which suggests that the prolongation of action is due, at least in part, to the inhibition by eserine of certain agents responsible for the inactivation of diacetylcholine.

Submitted on May 8, 1950




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Copyright © 1950 by the American Society for Pharmacology and Experimental Therapeutics.