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Journal of Pharmacology And Experimental Therapeutics, Vol. 99, Issue 4, 444-449, 1950
Copyright © 1950 by American Society for Pharmacology and Experimental Therapeutics

POTENTIATION OF THE ANTIMALARIAL ACTIVITY OF SULFADIAZINE BY 2,4-DIAMINO-5-ARYLOXYPYRIMIDINES

JOSEPH GREENBERG 1 and EDNA M. RICHESON 1

1 Microbiological Institute of the National Institutes of Health, Bethesda, Maryland

1. Twenty-two compounds were tested for their ability to potentiate the antimalarial activity of sulfadiazine against Plasmodium gallinaceum in the chick.

2. Only the two 2 ,4-diamino-5-aryloxypyrimidines were able to potentiate sulfadiazine activity in this infection. One quarter of the minimum effective dose of the diaminopyrimidines plus one-sixteenth of the minimum effective dose of sulfadiazine was the minimum effective regimen when these compounds were administered concurrently.

3. The antimalarial activity of the diaminopyrimidines was partially in hibited by large oral doses of pteroylglutamic acid.

Submitted on April 29, 1950




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