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Journal of Pharmacology And Experimental Therapeutics, Vol. 99, Issue 4, 435-443, 1950
Copyright © 1950 by American Society for Pharmacology and Experimental Therapeutics

PHARMACOLOGY OF A NEW AUTONOMIC GANGLION BLOCKING AGENT, 2, 6-DIMETHYL-1, 1-DIETHYL PIPERIDINIUM BROMIDE (SC-1950)

DONALD L. COOK 1, W. E. HAMBOURGER 1, and ROBERT C. BIANCHI 1

1 Pharmacology Department, Division of Biological Research, G. D. Searle & Co., Chicago, Illinois

Pharmacological actions of a new autonomic ganglion blocking agent, 2,6-dimethyl-1, 1-diethyl piperidinium bromide (SC-1950), are described. These chiefly result from autonomic ganglion blockade.

SC-1950 averages about five to seven times as effective as tetraethylammonium bromide in blocking the superior cervical (sympathetic) ganglion of the cat and the pelvic nerve (parasympathetic) ganglion of the dog.

SC-1950 reduces intestinal tone and contractility in anesthetized and unanesthetized dogs, following preliminary increase in tone. These effects are more pronounced on the circular than on the longitudinal muscle of the ileum of the anesthetized dog. It has little effect on acetylcholine spasm of the excised rabbit ileum.

Intravenous injections into anesthetized dogs produce a fall in blood pressure which is more prolonged with pentobarbital than with ether anesthesia.

SC-1950 exhibits a curare-like blockade on the frog muscle-nerve preparation. Large doses also produce curare-like effects in unanesthetized rabbits and dogs.

Acute toxicity data for mice, rats and dogs are given.

Submitted on April 17, 1950






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