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Journal of Pharmacology And Experimental Therapeutics, Vol. 99, Issue 4, 425-431, 1950
Copyright © 1950 by American Society for Pharmacology and Experimental Therapeutics

THE MECHANISM OF APNEA FOLLOWING INTRAVENOUS INJECTION OF VARIOUS ANTIHISTAMINIC COMPOUNDS; ITS RELATION TO THEIR CHEMICAL STRUCTURE

DOMINGO M. AVIADO JR. 1, ROBERT G. PONTIUS 1, and T. H. LI 1

1 Laboratory of Pharmacology, University of Pennsylvania, Philadelphia

Intravenous injection of some antihistaminic agents causes apnea through a reflex mechanism similar to that of veratridine. There are drug-sensitive receptors in the lungs causing inhibition of breathing.

Submitted on April 13, 1950






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