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Journal of Pharmacology And Experimental Therapeutics, Vol. 99, Issue 4, 421-424, 1950
Copyright © 1950 by American Society for Pharmacology and Experimental Therapeutics

A COMPARISON OF PROCAINE AND TRIDIURECAINE

G. CARL RAU 1 and B. A. WESTFALL 1

1 Department of Physiology and Pharmacology, University of Missouri School of Medicine, Columbia, Missouri

1. Studies on the toxicity and anesthetic potency of a procaine substituted diurethane (arbitrarily named tridiurecaine) have been reported.

2. The LD50 and the anesthetic potency of this drug and of procaine were determined and found to be approximately equal for both compounds.

3. The animals receiving high dosage of tridiurecaine did not exhibit the typical restlessness, tremors, excitability and convulsions characteristic of overdosage of procaine, but were sedated instead.

Submitted on March 31, 1950






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Copyright © 1950 by the American Society for Pharmacology and Experimental Therapeutics.