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Journal of Pharmacology And Experimental Therapeutics, Vol. 99, Issue 4, 401-408, 1950
Copyright © 1950 by American Society for Pharmacology and Experimental Therapeutics

A QUANTITATIVE STUDY OF BLOOD PRESSURE RESPONSE TO CARDIOVASCULAR DRUGS AND THEIR ANTAGONISTS

GRAHAM CHEN 1 and DAVID RUSSELL 1

1 Research Laboratories, Parke, Davis and Company, Detroit 32, Michigan

The graphical solutions of mass action equations by Lineweaver and Burk for monomolecular, competitive, and noncompetitive reactions have been utilized to study pharmacological reactions on blood pressure. Competitive inhibition is shown for epinephrine-SY 28, epinephrine-yohimbine, acetylcholine-atropine, and histamine-diphenhydramine. Noncompetitive inhibition is indicated with a large quantity of SY 28. Ergotamine antagonizes the vasodepressor response to histamine uncompetitively.

The usefulness and limitations in the quantitation and elucidation of pharmacological reactions by the mass action law are pointed out.

Submitted on March 30, 1950






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Copyright © 1950 by the American Society for Pharmacology and Experimental Therapeutics.