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Journal of Pharmacology And Experimental Therapeutics, Vol. 99, Issue 3, 366-369, 1950
Copyright © 1950 by American Society for Pharmacology and Experimental Therapeutics

EFFECT OF CARINAMIDE (4' CARBOXYPHENYLMETHANE SULFONANILIDE) ON THE METABOLISM OF THIOPENTAL IN MICE

Leo R. Goldbaum 1 and Theodore F. Hubbard 2

1 Department of Chemistry and Physics, and the Department of Basic Science, Army Medical Department Research and Graduate School, Washington 12, D. C.
2 Mayo Clinic, Rochester, Minnesota

Carinamide has been shown to prolong the sedative effects of thiopental, pentobarbital, and seconal in mice. The observed increase in thiopental sleeping time was proportional to the size of the carinamide dose and appeared to be due to the interference by carinamide with the degradation of thiopental. The rate of degradation of thiopental was inversely proportional to the size of the carinamide dose.

Submitted on March 27, 1949






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