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Journal of Pharmacology And Experimental Therapeutics, Vol. 99, Issue 3, 353-361, 1950
Copyright © 1950 by American Society for Pharmacology and Experimental Therapeutics

SOME PHARMACOLOGICAL PROPERTIES OF A SERIES OF ACETAMIDINES AND PROPIONAMIDINES

Bradford N. Craver 1, Anne Cameron 1, and Walter Barrett 1

1 Research Department, Division of Macrobiology, Ciba Pharmaceutical Products, Inc., Summit, New Jersey

1. The general pharmacological properties of a series of acetamidines and propionamidines have been presented.

2. A small minority of the amidines exhibited marked anticholinergic and somewhat less marked antihistaminic activity. The presumed structural requisites to those actions have been discussed.

3. A minority of the amidines comprised a second group that exhibited marked positive inotropic and chronotropic effects upon the perfused heart and the heartlung preparation. The presumed structural requisites to that action have been discussed in detail.

Submitted on March 23, 1950






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