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Journal of Pharmacology And Experimental Therapeutics, Vol. 99, Issue 3, 304-311, 1950
Copyright © 1950 by American Society for Pharmacology and Experimental Therapeutics

ACTIVITY OF SOME NEWER SPASMOLYTIC AGENTS ON THE BILIARY TRACT OF MAN

A Comparative Study of Isopropyl-Norepinephrine, Adiphenine Hydrochloride, Methylamino-iso-octene and Khellin

Edward A. Gaensler 1 and John M. McGowan 1

1 Henderson Laboratory, Fourth Surgical Service, Boston City Hospital, and Tufts College Medical School, Boston, Mass.

Intrabiliary pressures were measured 137 times in 40 patients who had previous exploration of the common bile duct with T-tube drainage.

On fifteen occasions pressures were found to be spontaneously elevated due to spasm of the second portion of the duodenum. For all other studies spasm was induced by opiates, meperidine, methadone and Metopon.

Isopropyl-norepinephrine, methylamino-iso-octene, khellin and adiphenine, all administered parenterally, were found to have no effect on spontaneous or drug-induced spasm.

Inhalation of amyl nitrite and intravenous injection of aminophylline invariably caused rapid and complete relief of spontaneous as well as induced spasm. Duration of action of both drugs was very brief.

Of the many spasmolytics now available, none fulfill the requirements of a long acting, potent, specific, smooth muscle relaxing agent in the treatment of duodenal spasm related to biliary colic.

Submitted on March 7, 1950






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Copyright © 1950 by the American Society for Pharmacology and Experimental Therapeutics.