JPET Introducing ALZET?ew Model 2006 Pump

Home Help [Feedback] [For Subscribers] [Archive] [Search] [Contents]
QUICK SEARCH:   [advanced]


     

This Article
Right arrow Full Text (PDF)
Right arrow Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Melville, K. I.
Right arrow Articles by Lu, F. C.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Melville, K. I.
Right arrow Articles by Lu, F. C.
Journal of Pharmacology And Experimental Therapeutics, Vol. 99, Issue 3, 286-303, 1950
Copyright © 1950 by American Society for Pharmacology and Experimental Therapeutics

EFFECTS OF EPINEPHRINE, AMINOPHYLLINE, NITROGLYCERINE AND PAPAVERINE ON CORONARY INFLOW AND ON HEART CONTRACTION, AS RECORDED CONCURRENTLY

K. I. Melville 1 and F. C. Lu 2

1 Department of Pharmacology, McGill University, Montreal, Canada
2 Medical Research Fellow, National Research Council, Canada

1. The changes occurring concurrently in coronary flow and heart contraction have been recorded continuously in the isolated perfused rabbit heart, before and after injections of varying doses of epinephrine, aminophylline, nitroglycerine and papaverine.

2. The results indicate that epinephrine per se exerts neither a significant direct coronary vasoconstrictor nor a coronary vasodilator action, but in most of the experiments the coronary flow per heart beat is decreased due to the mechanical effects of the myocardial stimulation. The usually observed increase in the rate of coronary flow in the rabbit heart after epinephrine appears to be a secondary effect resulting from the cardiac stimulation, and may be due to some metabolite released during the intense stimulation of the myocardium.

3. Aminophylline, nitroglycerine and papaverine, in suitable doses all induce direct coronary vasodilatation, and the rate of coronary flow per heart beat is increased. In addition, (a) small doses of aminophylline increase the rate and amplitude of the heart contractions; with large doses, these effects are accentuated and may even decrease the rate of coronary flow per heart beat; (b) small doses of nitroglycerine slow the heart rate but lead to little change in the amplitude of contractions, but with large doses, coronary flow per heart beat is markedly increased due to myocardial depression; (c) small doses of papaverine exert little effect on rate or amplitude, but with increasing doses the heart rate is progressively increased and the amplitude of the contractions reduced, due to a decrease in both systole and diastole; these changes may decrease the rate of coronary flow per heart beat.

The possible significance of the above findings is discussed.

Submitted on February 3, 1950




This article has been cited by other articles:


Home page
 ANGIOLOGYHome page
A. F. Heck and I. Hawthorne
Responses in the Microcirculation of the Conjuctiva to Systemic Administration of Papaverine HCl
Angiology, January 1, 1971; 22(7): 408 - 420.
[PDF]


Home Help [Feedback] [For Subscribers] [Archive] [Search] [Contents]
All ASPET Journals Molecular Pharmacology Pharmacological Reviews
Molecular Interventions Drug Metabolism and Disposition

Copyright © 1950 by the American Society for Pharmacology and Experimental Therapeutics.