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Journal of Pharmacology And Experimental Therapeutics, Vol. 99, Issue 2, 202-214, 1950
Copyright © 1950 by American Society for Pharmacology and Experimental Therapeutics

EVALUATION OF AGENTS WITH THYROXINE-INHIBITING EFFECTS

S. B. Barker 1, C. E. Kiely Jr. 1, H. B. Dirks Jr. 1, H. M. Klitgaard 1, S. C. Wang 1, and S. Wawzonek 1

1 Departments of Physiology and Chemistry, State University of Iowa, Iowa City

Several substances have been tested for thyroxine-inhibiting action using the following criteria: (1) lowering the BMR of normal rats, (2) lowering the thyroxine-elevated BMR of thyroidectomized rats, (3) reversal of thyroxine depression of estrogen responsiveness.

Among the compounds showing some ability to overcome thyroxine effects were: Iodinated phenoxyacetic acids, 4-hydroxy- and 4-benzyloxy-3,5-diiodobenzoic acids and N-(4'-hydroxy-3',5'-diiodobenzoyl)-3,5-diiodotyrosine. In contrast, 3,5-diiodo-L-tyrosine and 3,5-dibromo-L-tyrosine showed no activity.

Submitted on February 28, 1950






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Copyright © 1950 by the American Society for Pharmacology and Experimental Therapeutics.