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Journal of Pharmacology And Experimental Therapeutics, Vol. 99, Issue 1, 38-44, 1950
Copyright © 1950 by American Society for Pharmacology and Experimental Therapeutics

THE LEVATOR ANI MUSCLE OF THE RAT AS AN INDEX OF MYOTROPHIC ACTIVITY OF STEROIDAL HORMONES

Eugene Eisenberg 1 and Gilbert S. Gordan 1

1 Division of Pharmacology and Experimental Therapeutics and the Division of Medicine, University of California School of Medicine, San Francisco 22

1. The effects of castration and of various steroids upon the weight and water content of the levator ani muscle of the male rat were studied. This muscle is notably smaller in the castrate than in the normal rat at 60 days and can be restored to normal weight, or even rendered hypertrophic, by the administration of certain steroids.

2. The response in weight of the levator ani muscle to administration of various steroids parallels closely their known protein-anabolic activity. The myotrophic effect is distinct from the androgenic effect.

3. By this assay, pituitary growth hormone, unesterified testosterone, testosterone propionate and methyl testosterone are potent myotrophic agents; progesterone is moderately active; and estradiol dipropionate, cis-testosterone, desoxycorticosterone acetate, and ethinyl testosterone produce no significant increase in weight of the muscle.

Submitted on January 17, 1950




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Copyright © 1950 by the American Society for Pharmacology and Experimental Therapeutics.