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Journal of Pharmacology And Experimental Therapeutics, Vol. 99, Issue 1, 140-148, 1950
Copyright © 1950 by American Society for Pharmacology and Experimental Therapeutics

SHORT-TERM ORAL TOXICITY TESTS OF METHOXYCHLOR (2,2 DI-(P-METHOXY PHENYL)-1,1,1-TRICHLORETHANE) IN RATS AND DOGS

Harold C. Hodge 1, Elliott A. Maynard 1, Joan F. Thomas 1, H. J. Blanchet Jr. 1, W. G. Wilt Jr. 1, and Karl E. Mason 1

1 Division of Pharmacology & Toxicology, University of Rochester School of Medicine and Dentistry, Rochester, New York

1. In rats, the acute oral toxicity of methoxychlor is low.

2. In short-term feeding tests, ten male and ten female rats were maintained for about 45 days on diets containing 0 (a control group), 0.01, 0.1 and 3 per cent methoxychlor, respectively. The addition of 0.1 per cent produced a small but detectable growth depression. Practically no growth occurred on diets containing 3 per cent methoxychior and eight of ten rats (both male and female) died.

3. A paired-feeding test was conducted in which ten male and ten female rats of the experimental group were maintained on a diet containing 1 per cent methoxychlor. Voluntary food refusal was shown to be responsible for most of the growth retardation. The testes were extraordinarily small in the experimental rats.

Submitted on February 6, 1950




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Copyright © 1950 by the American Society for Pharmacology and Experimental Therapeutics.