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Journal of Pharmacology And Experimental Therapeutics, Vol. 98, Issue 4, 418-426, 1950
Copyright © 1950 by American Society for Pharmacology and Experimental Therapeutics

A COMPARISON OF SEVERAL DOSE-ACTION CURVES FOR THE PRESSOR ACTION OF EPINEPHRINE

ROBERT V. BROWN 1

1 Division of Pharmacology, University of Tennessee , Memphis

1. The most accurate dose-action curve for the pressor action of epinephrine is Rosenblueth's hyperbola: y = x/(a + bx)0 le x le 100.

2. A similar hyperbola most accurately relates maximum blood pressure attained with the dose of epinephrine: Y = x/(A + Bx) 0 le x le 100.

3. Of the two equations, the one for the pressor action is the more accurate.

4. Hyperbolic equations yield the only curves which will fit the data accurately over the entire dosage range used.

5. The official assay can be extended in range by use of a correct dose-action curve for the pressor action of epinephrine.

Submitted on January 16, 1950






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