JPET Celsis microsomes equal better data

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Journal of Pharmacology And Experimental Therapeutics, Vol. 98, Issue 4, 405-408, 1950
Copyright © 1950 by American Society for Pharmacology and Experimental Therapeutics

STUDIES ON DIETHYLAMINOETHANOL

II. Antiarrhythmic Activity in Two Homologous Alcohol Series

LESTER C. MARK 1, W. A. LOTT 1, JACK R. COOPER 1, and BERNARD B. BRODIE 1

1 Research Service, Third (New York University) Medical Division, Goldwater Memorial Hospital; Department of Anesthesiology, New York University-Bellevue Medical Center; Department of Biochemistry, New York University College of Medicine, New York City; Squibb Institute for Medical Research, New Brunswick, N. J.

Diethylaminoethanol was found to be the only effective member in nontoxic doses of two homologous series of dialkylaminoalcohols screened for quinidinelike action in dogs, using cyclopropane-epinephrine-induced ventricular tachycardia as the test object.

Submitted on January 11, 1950






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Copyright © 1950 by the American Society for Pharmacology and Experimental Therapeutics.