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Journal of Pharmacology And Experimental Therapeutics, Vol. 98, Issue 4, 358-365, 1950
Copyright © 1950 by American Society for Pharmacology and Experimental Therapeutics

EFFECT OF CONVULSANT AND ANTICONVULSANT AGENTS ON THE ACTIVITY OF OXALACETIC AND PYRUVIC CARBOXYLASE

CLARA TORDA 1 and HAROLD G. WOLFF 1

1 The New York Hospital, the Kingsbridge Hospital (V.A.); Departments of Medicine (Neurology) and Psychiatry, Cornell University Medical College, New York, N. Y.

The effects of certain convulsant and anticonvulsant agents on the activity of oxalacetic and pyruvic carboxylase were investigated.

The activity of the carboxylases was inhibited by the convulsant agents.

The activity of the carboxylases was somewhat increased in the presence of the anticonvulsant agents used and was not modified in the presence of Tridione and choline in concentrations from 1 x 10-3 to 1 x 10-5M.

Submitted on December 31, 1949






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Copyright © 1950 by the American Society for Pharmacology and Experimental Therapeutics.