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Journal of Pharmacology And Experimental Therapeutics, Vol. 98, Issue 3, 245-250, 1950
Copyright © 1950 by American Society for Pharmacology and Experimental Therapeutics

THE INFLUENCE OF DIPHENHYDRAMINE·HC1 (BENADRYL) ON APOMORPHINE-INDUCED EMESIS IN DOGS

GRAHAM CHEN 1 and CHARLES R. ENSOR 1

1 Research Department, Parke, Davis & Company, Detroit 32, Michigan

Diphenhydramine·HCl (Benadryl) has been found to have an antiemetic effect against apomorphine-induced vomiting in dogs. Diphenhydramine-8-chlorotheophylline in equivalent doses of diphenhydramine is equally effective while 8-chlorotheophylline is ineffective in suppressing emesis. Phenobarbital and atropine are effective only in hypnotic doses.

The mode of action of diphenhydramine·HCl in anti-emesis and its indication in pernicious vomiting of pregnancy, and in sea and air sickness are suggested.

Submitted on November 12, 1949




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S. R. BERSACK and T. E. WHITAKER Jr.
EFFECT OF DIPHENHYDRAMINE (BENADRYL(R)) ON SIDE-REACTIONS IN INTRAVENOUS UROGRAPHY
Arch Intern Med, May 1, 1953; 91(5): 618 - 625.
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Copyright © 1950 by the American Society for Pharmacology and Experimental Therapeutics.