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Journal of Pharmacology And Experimental Therapeutics, Vol. 98, Issue 3, 224-233, 1950
Copyright © 1950 by American Society for Pharmacology and Experimental Therapeutics

ENERGY METABOLISM OF RABBIT INTESTINE AS INFLUENCED BY METABOLIC BLOCKING AGENTS

JAMES R. WEEKS 1, MAYNARD B. CHENOWETH 1, and FREDERICK E. SHIDEMAN 1

1 Department of Pharmacology, University of Michigan, Ann Arbor

Although both sodium dehydroacetate and sodium malonate are inhibitors of succinic acid dehydrogenase, only the former interferes with the maintenance of spontaneous contractile activity of the isolated rabbit intestine by sodium acetate. Sodium fluoroacetate like sodium dehydroacetate blocks the utilization of sodium acetate. Glucose maintains appreciable contractile activity even in the presence of high concentrations of fluoroacetate. Sodium fluoroacetate has no significant influence upon the oxygen uptake of isolated segments of rabbit intestine mounted in either sodium acetate or glucose containing media, although mechanical activity is profoundly diminished.

Submitted on November 1, 1949






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Copyright © 1950 by the American Society for Pharmacology and Experimental Therapeutics.