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Journal of Pharmacology And Experimental Therapeutics, Vol. 98, Issue 3, 215-223, 1950
Copyright © 1950 by American Society for Pharmacology and Experimental Therapeutics

THE INFLUENCE OF DRUGS ON THE IRRITABILITY AND AUTOMATICITY OF HEART MUSCLE

THEODORE H. GREINER 1 and SOLOMON GARB 1

1 Department of Pharmacology, Cornell University Medical College, New York City

1. The effects of seven ions and sixteen drugs on the irritability and automaticity of heart muscle are reported.

2. The cations studied, other than barium, all raised the threshold of irritability. The curves for lithium and sodium were similar. Potassium and ammonium raised the threshold of irritability sharply, beyond a certain concentration. Calcium and magnesium produced a slight rise in threshold. The response to barium was erratic.

3. The sympathomimetic amines all lowered the threshold of irritability and all produced spontaneous rhythms. The N-isopropyl homologue of epinephrine was most effective in lowering the threshold, but produced less automaticity than the other homologues.

4. Papaverine and aminophylline lowered the threshold of irritability, while quinidine and procaine elevated it, in concentrations which are attainable in an intact animal.

5. Atropine, acetylcholine, and acetyl-beta-methylcholine had no demonstrable effect on irritability or automaticity.

6. The difference between irritability and automaticity of myocardium is illustrated by the changes induced by drugs.

Submitted on November 1, 1949




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