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Journal of Pharmacology And Experimental Therapeutics, Vol. 98, Issue 2, 184-187, 1950
Copyright © 1950 by American Society for Pharmacology and Experimental Therapeutics

THE ABSENCE OF LOCALIZATION OF BARBITAL IN DIVISIONS OF THE CENTRAL NERVOUS SYSTEM

E. W. Maynert 1 and H. B. Van Dyke 1

1 Department of Pharmacology, College of Physicians and Surgeons, Columbia University, New York 32, N. Y.

The view that barbital is excreted only as unchanged drug was confirmed by the use of barbital labeled with N15. The concentration of the isotopic barbital was determined in various parts of the brain of four dogs after doses ranging from 25 to 250 mgm. per kgm. No localization in a particular division of the central nervous system such as the diencephalon was present.

Submitted on November 16, 1949




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A. Heller, J. A. Harvey, H. F. Hunt, and L. J. Roth
Effect of Lesions in the Septal Forebrain of the Rat on Sleeping Time under Barbiturate
Science, March 4, 1960; 131(3401): 662 - 664.
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