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Journal of Pharmacology And Experimental Therapeutics, Vol. 98, Issue 2, 174-179, 1950
Copyright © 1950 by American Society for Pharmacology and Experimental Therapeutics

THE METABOLIC FATE OF PENTOBARBITAL

Isotope Dilution Experiments with Urine after the Administration of Labeled Pentobarbital

E. W. Maynert 1 and H. B. Van Dyke 1

1 Department of Pharmacology, College of Physicians and Surgeons, Columbia University, New York 32, N. Y.

Isotope dilution experiments with the urine of dogs after the administration of pentobarbital labeled with N15 revealed that only negligible amounts of ethyl (1-methylbutyl) acetyl urea and the similarly substituted acetamide and malonamide were present as metabolic products of the drug. The results of similar experiments with ethyl (1-methylbutyl) malonuric acid which indicated the excretion of this compound as a metabolite were shown to be erroneous due to coprecipitation.

Ethyl (1-methylbutyl) malonuric acid and the corresponding malonamide were found to possess no hypnotic activity in mice.

Submitted on November 16, 1949






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