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Journal of Pharmacology And Experimental Therapeutics, Vol. 98, Issue 2, 144-146, 1950
Copyright © 1950 by American Society for Pharmacology and Experimental Therapeutics

THE EFFECT OF INTRAMUSCULAR DIHYDROERGOCORNINE ON THE CEREBRAL CIRCULATION IN NORMOTENSIVE PATIENTS

Joseph H. Hafkenschiel 1, Charles W. Crumpton 1, and John H. Moyer 2

1 Edward B. Robinette Foundation, Medical Clinic, Hospital of the University of Pennsylvania, Philadelphia, Penna.
2 Department of Pharmacology, University of Pennsylvania, Philadelphia, Penna.

1. Measurements of cerebral blood flow, cerebral arteriovenous oxygen difference and mean arterial blood pressure were made by the nitrous oxide method before and after the intramuscular injection of dihydroergocornine in six tests on five normotensive subjects.

2. Cerebral blood flow and cerebral oxygen uptake were essentially unchanged although mean arterial pressure was significantly decreased. Cerebral vascular resistance decreased slightly but not significantly. The cerebral circulatory response of normotensive patients differed from that of hypertensive patients following clihydroergocornine in that the cerebral vascular resistance was not significantly decreased.

Submitted on October 31, 1949






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