JPET Introducing ALZET?ew Model 2006 Pump

Home Help [Feedback] [For Subscribers] [Archive] [Search] [Contents]
QUICK SEARCH:   [advanced]


     

This Article
Right arrow Full Text (PDF)
Right arrow Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Wolff, J.
Right arrow Articles by Chaikoff, I. L.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Wolff, J.
Right arrow Articles by Chaikoff, I. L.
Journal of Pharmacology And Experimental Therapeutics, Vol. 98, Issue 1, 45-48, 1950
Copyright © 1950 by American Society for Pharmacology and Experimental Therapeutics

THE INFLUENCE OF 2,4-DINITROPHENOL ON PLASMA PROTEIN-BOUND IODINE

J. Wolff 1, L. Rubin 1, and I. L. Chaikoff 1

1 Division of Physiology of the University of California Medical School, Berkeley

1. 2,4-Dinitrophenol (DNP) was injected intraperitoneally into rats for 1 to 29 days. A characteristic finding in all rats so treated was a lowering in the concentrations of protein-bound iodine of plasma to approximately half those found in the control animals.

2. This fall in the level of plasma protein-bound iodine was not accompanied by an enlargement of the thyroid gland nor by a change in its histological appearance. Moreover, the amounts of total and thyroxine-like iodine of the gland were unaffected.

The uptake of injected I131 and its conversion to organic forms by the thyroid gland of DNP-treated rats remained normal.

Submitted on August 15, 1949






Home Help [Feedback] [For Subscribers] [Archive] [Search] [Contents]
All ASPET Journals Molecular Pharmacology Pharmacological Reviews
Molecular Interventions Drug Metabolism and Disposition

Copyright © 1950 by the American Society for Pharmacology and Experimental Therapeutics.