JPET Celsis microsomes equal better data

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Journal of Pharmacology And Experimental Therapeutics, Vol. 97, Issue 3, 379-383, 1949
Copyright © 1949 by American Society for Pharmacology and Experimental Therapeutics

COMPARISON OF SMOOTH MUSCLE EFFECTS OF CROTONOSIDE (ISOGUANOSINE) AND ADENOSINE

PAUL L. EWING 1, FRITZ SCHLENK 1, and GEORGE A. EMERSON 1

1 Department of Pharmacology, Universily of Texas Medical Branch, Galveston, Texas; Department of Bacteriology, Iowa State College, Ames, Iowa

Crotonoside (isoguanosine) has been shown to be much more active than adenosine in reducing the blood pressure in rabbits and cats, in decreasing the tone of isolated intestinal strips of the rabbit, guinea pig and hamster and in stimulating the isolated uterus of guinea pigs and hamsters.

The difference in activity of these two compounds is considerably more marked with the guinea pig tissues than with those of the rabbit, cat or hamster.

Possible relationships to theories of action of adenosine are discussed.

Submitted on August 8, 1949




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F. Fuhrman, G. Fuhrman, R. Nachman, and H. Mosher
Isoguanosine: isolation from an animal
Science, May 1, 1981; 212(4494): 557 - 558.
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Copyright © 1949 by the American Society for Pharmacology and Experimental Therapeutics.