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Journal of Pharmacology And Experimental Therapeutics, Vol. 97, Issue 3, 349-357, 1949
Copyright © 1949 by American Society for Pharmacology and Experimental Therapeutics

THE SYSTEMIC ACTIONS OF THIOGLYCEROL WITH SPECIAL REFERENCE TO GOITROGENIC ACTIVITY

CHARLES J. KENSLER 1 and ROBERT W. ELSNER 1

1 Department of Pharmacology, Cornell University Medical College, New York City

1. Acute poisoning by thioglycerol resembles that produced by BAL, but not that produced by thioglycolic acid.

2. Barbital decreases mortality in rats poisoned with thioglycerol.

3. Thioglycerol when administered repeatedly in large doses possesses weak goitrogenic action in the rat and rabbit. Thioglycolic acid possesses no detectable goitrogenic activity.

Submitted on August 2, 1949






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Copyright © 1949 by the American Society for Pharmacology and Experimental Therapeutics.