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Journal of Pharmacology And Experimental Therapeutics, Vol. 97, Issue 3, 331-341, 1949
Copyright © 1949 by American Society for Pharmacology and Experimental Therapeutics

A NEUROPHARMACOLOGICAL STUDY ON THE EFFECT OF MYANESIN (TOLSEROL) ON MOTOR SYSTEMS

ELWOOD HENNEMAN 1, ARNOLD KAPLAN 1, and KLAUS UNNA 1

1 Departments of Psychiatry and Pharmacology, University of Illinois, College of Medicine

New techniques have been described whereby drugs affecting the extrapyramidal system may be tested. With them it has been demonstrated that:

(1) Myanesin decreases or abolishes facilitation and inhibition reaching anterior horn cells from all levels of the C.N.S.

(2) Neural circuits containing internuncial cells are vulnerable to Myanesin, whereas "direct" circuits withstand large doses without effect.

(3) Relief of spasticity by Myanesin can be explained in terms of these effects.

(4) The site of action of Myanesin is probably the internuncial cell.

Submitted on August 1, 1949




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Copyright © 1949 by the American Society for Pharmacology and Experimental Therapeutics.