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Journal of Pharmacology And Experimental Therapeutics, Vol. 97, Issue 3, 283-291, 1949
Copyright © 1949 by American Society for Pharmacology and Experimental Therapeutics

AN ULTRAVIOLET SPECTROPHOTOMETRIC METHOD FOR THE DETERMINATION OF THEOPHYLLINE AND THEOBROMINE IN BLOOD AND TISSUES

JEROME A. SCHACK 1 and SAMUEL H. WAXLER 1

1 Basic Science Dept., Army Medical Dept., Research and Graduate School, Army Medical Center, Washington 12, D. C.

1. A simple, rapid and accurate ultraviolet spectrophotometric method for the determination of theophylline and theobromine in biological fluids has been developed.

2. The method offers satisfactory precision and a sensitivity of 1.0 microgm. per cc.

3. Application of the method to the tissue of rabbits and mice has been shown.

4. Theophylline has been demonstrated to be restricted to the plasma of the circulating blood.

5. Theophylline has been demonstrated to be very loosely bound to the plasma proteins.

6. The tissue level of theophylline following intravenous administration has been found to parallel the blood level in its rate of fall.

Submitted on July 14, 1949




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Copyright © 1949 by the American Society for Pharmacology and Experimental Therapeutics.