JPET Celsis microsomes equal better data

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Journal of Pharmacology And Experimental Therapeutics, Vol. 97, Issue 3, 276-282, 1949
Copyright © 1949 by American Society for Pharmacology and Experimental Therapeutics

THERAPEUTIC AND TOXIC PROPERTIES OF OXYGEN VERSUS SULFUR BOUND TRIVALENT ANTIMONY IN ORGANIC ANTIMONIALS

GEORGE W. LUTTERMOSER 1, W. T. HASKINS 1, and F. J. BRADY 1

1 Laboratory of Tropical Diseases, National Institutes of Health, Bethesda, Maryland

A comparison was made of the effects of ammonium antimonyl malate, ammonium antimonyl thiomalate, lithium antimonyl malate, and lithium antimonyl thiomalate on normal white mice and also on Schistosoma mansoni infections in these animals. The four compounds contain antimony bound to carbon through oxygen or through sulfur. No marked differences in toxicity and therapeutic effects were found that could be attributed to the type of antimony linkage.

Submitted on July 12, 1949






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Copyright © 1949 by the American Society for Pharmacology and Experimental Therapeutics.