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Journal of Pharmacology And Experimental Therapeutics, Vol. 97, Issue 2, 243-249, 1949
Copyright © 1949 by American Society for Pharmacology and Experimental Therapeutics

THE EFFECTS OF VARIOUS FLAVONE GLUCOSIDES ON THE RATE OF PASSAGE OF EVANS BLUE THROUGH THE DAMAGED CAPILLARY WALL

DAVID F. BOHR 1, BARBARA C. McIVOR 1, and JAMES F. RINEHART 1

1 Division of Pathology, University of California Medical School, San Francisco, California

1) The influence of various flavones on the rate of diffusion of Evans blue through the capillary wall damaged by heat was determined in an attempt to assay the effect of these materials on capillary permeability.

2) Rutin was about 40 per cent as effective as hesperidin methyl chalcone (H.M.C.) in producing a delay in skin colorization time. Sodium hesperidin chalcone was about 30 per cent as effectiveas H.M.C.

3) Evidence was presented which suggests that the delay in colorization time produced by these flavones was due largely to a decrease in capillary blood flow in the skin and hence cannot be used to evaluate changes in permeability of the capillary wall.

4) H.M.C. produced a greater and more sustained fall in blood pressure than did the other flavones.

Submitted on July 18, 1949




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Copyright © 1949 by the American Society for Pharmacology and Experimental Therapeutics.