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Journal of Pharmacology And Experimental Therapeutics, Vol. 97, Issue 2, 229-237, 1949
Copyright © 1949 by American Society for Pharmacology and Experimental Therapeutics

ABSORPTION AND DISTRIBUTION OF ISOPROPYL ALCOHOL

JOAN WAX 1, FRED W. ELLIS 1, and ARNOLD J. LEHMAN 1

1 Department of Pharmacology, School of Medicine, University of North Carolina, Chapel Hill

1. Absorption of isopropyl alcohol occurred from all portions of the digestive tract, most rapidly in the intestine as a whole and least in the stomach. During a 30-minute absorption period isopropyl alcohol was distributed to the spinal fluid and all tissues examined; i.e. brain, liver, kidney, and skeletal muscle. Spinal fluid and blood concentrations were approximately equal, but there was no constant relationship between tissue and blood concentrations. Increased absorption area did not apparently influence total absorption during a 30-minute period, but perhaps allowed more complete distribution to tissues because of earlier average absorption.

2. The percentage absorption and distribution was not definitely affected by the concentration.

3. At the end of two hours the absorption of isopropyl alcohol was 99 per cent complete, the greatest part (82 per cent) occurring within the first 30 minutes.

4. Previous absorption of isopropyl alcohol from intestinal loops did not definitely influence absorption from adjacent loops.

5. Ethyl alcohol administered intravenously might have exerted someinhibition on the intestinal absorption of isopropyl alcohol.

Submitted on July 13, 1949






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