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Journal of Pharmacology And Experimental Therapeutics, Vol. 97, Issue 2, 222-228, 1949
Copyright © 1949 by American Society for Pharmacology and Experimental Therapeutics

THE ABSORPTION, DISTRIBUTION AND EXCRETION OF d,l METHADONE

E. LEONG WAY 1, CHEN-YÜ SUNG 1, and WILLIAM P. McKELWAY 1

1 Department of Pharmacology, The George Washington University Medical School, Washington,D. C.; Division of Pharmacology and Experimental Therapeutics; Collegeof Pharmacy, University of California Medical Center, San Francisco, California

1. A method for determining d,l methadone in biologic samples is described.

2. d,l Methadone is well absorbed when given orally.

3. The compound concentrates mainly in the liver, kidney, lungs and spleen. Low levels are found in blood, heart and muscle.

4. Only a very small fraction of d,l methadone appears in the feces and urine unchanged.

Submitted on July 13, 1949




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Copyright © 1949 by the American Society for Pharmacology and Experimental Therapeutics.